Hebbian plasticity requires compensatory processes on multiple timescales

Hebbian plasticity requires compensatory processes on multiple timescales

We review a body of theoretical and experimental research on Hebbian and homeostatic plasticity, starting from a puzzling observation: while homeostasis of synapses found in experiments is a slow compensatory process, most mathematical models of synaptic plasticity use rapid compensatory processes (RCPs). Even worse, with the slow homeostatic plasticity reported in experiments, simulations of e...

Cooperation across timescales between and Hebbian and homeostatic plasticity

We review a body of theoretical and experimental research on the interactions of homeostatic and Hebbian plasticity, starting from a puzzling observation: While homeostasis of synapses found in experiments is slow, homeostasis of synapses in most mathematical models is rapid, or even instantaneous. Even worse, most existing plasticity models cannot maintain stability in simulated networks with ...

The temporal paradox of Hebbian learning and homeostatic plasticity.

Hebbian plasticity, a synaptic mechanism which detects and amplifies co-activity between neurons, is considered a key ingredient underlying learning and memory in the brain. However, Hebbian plasticity alone is unstable, leading to runaway neuronal activity, and therefore requires stabilization by additional compensatory processes. Traditionally, a diversity of homeostatic plasticity phenomena ...

Hebbian Learning and Plasticity

Beyond Hebbian plasticity: Effective learning with ineffective Hebbian learning rules

In this paper we revisit the classical neuroscience paradigm of Hebbian learning. We find that a necessary requirement for effective associative memory learning is that the efficacies of the incoming synapses should be uncorrelated. This is difficult to achieve in a robust manner by Hebbian synaptic learning, since it depends on network level information. Effective learning can yet be achieved ...